HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Ethyl6-(3-hydroxyphenyl)pyridine-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Ethyl6-iodonicotinoate | HCID 10891136 | — |
| Reactant | (3-(Methoxymethoxy)phenyl)boronic acid | HCID 22606941 | — |
| Catalyst | HCID 178418397 | HCID 178418397 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | Ethyl6-(3-hydroxyphenyl)pyridine-3-carboxylate | HCID 22606943 | — |
Reaction Steps
In a manner similar to that of Example 1(h), by reaction of 1 g (6.7 mmol) of 3-methoxymethoxyphenylboronic acid (described in Example l(g)) and 1.5 g (5.6 mmol) of ethyl 6-iodonicotinate with 5.6 mL of 2.0M potassium carbonate and 320 mg of tetrakis(triphenylphosphine)palladium, followed by deprotection in ethanol, the desired product is obtained in the form of a white solid (m=354 mg; Y=26%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06831106B1 |
| Source dataset | uspto-grants-2004_12 |
| ORD ID | ord-9aa6332d9ba946829586647fdc9327ce |
| Source note | uspto-grants-2004_12 |