Potassium Carbonate → Methyl 5'-hydroxy-2,2'-dimethylbiphenyl-4-carboxylate

Participants

Reaction Steps

In a manner similar to that of Example 11(d), by reaction of 3.7 g (18.8 mmol) of 4-methoxymethoxy-1-methylbenzene-2-boronic acid with 3.9 g (17 mmol) of methyl 4-bromo-3-methylbenzoate, 17 mL of 2.0M potassium carbonate solution and 1 mg (0.85 mmol) of tetrakis(triphenylphosphine)palladium, followed by deprotection in methanol, the desired product is obtained in the form of a thick, colourless oil (m=2.87 mg; Y=51%).

Provenance & Evidence