Potassium Carbonate → Methyl 5'-hydroxy-2,6,2'-trimethylbiphenyl-4-carboxylate

Participants

Reaction Steps

In a manner similar to that of Example 11(d), by reaction of 3.7 g (18.8 mmol) of 4-methoxymethoxy-1-methylbenzene-2-boronic acid (described in Example 16(c)) with 5.3 g (17 mmol) of methyl 3,5-dimethyl-4-trifluoromethanesulphonyloxybenzoate, 17 mL of 2.0M potassium carbonate solution and 1 g (0.82 mmol) of tetrakis(triphenylphosphine)palladium, followed by deprotection in methanol, the desired product is obtained in the form of a yellow oil (m=3.0 g; Y=65%).

Provenance & Evidence