Potassium Carbonate → Ethyl 5'-hydroxy-2'-methylbiphenyl-4-carboxylate

Participants

Reaction Steps

In a manner similar to that of Example 11(d), by reaction of 3.7 g (18.8 mmol) of 4-methoxymethoxy-1-methylbenzene-2-boronic acid described in Example 16(c) with 4.7 g (17 mmol) of ethyl 4-iodobenzoate, 17 mL of 2.0M potassium carbonate solution and 1 g (0.8 mmol) of tetrakis(triphenylphosphine)palladium, followed by deprotection in ethanol, the desired product is obtained in the form of a colourless oil (m=3.07 g; Y=71%).

Provenance & Evidence