HuagongsheHuagongshe Chemistry Print Report · For research reference only
Potassium Carbonate → Methyl 4'-hydroxy-2-methylbiphenyl-4-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | 4-Bromo-3-methylbenzoic acid | HCID 82131 | — |
| Reactant | 4-(Methoxymethoxy)phenylboronic acid | HCID 2762528 | — |
| Catalyst | Tetrakis(triphenylphosphine)palladium | HCID 11979704 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 4'-hydroxy-2-methylbiphenyl-4-carboxylate | HCID 22606882 | — |
Reaction Steps
In a manner similar to that of Example 1(h), by reaction of 1.61 g (8.7 mmol) of 4-methoxymethoxy-phenylboronic acid and 1.8 g (9.7 mmol) of 4-bromo-3-methylbenzoic acid with 26.7 mL of 2.0M potassium carbonate and 1.54 g of tetrakis(triphenylphosphine)-palladium, followed by deprotection-esterification in methanol, the desired product is obtained in the form of a colourless oil (m=2.06 g; Y=98%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06831106B1 |
| Source dataset | uspto-grants-2004_12 |
| ORD ID | ord-8b5b5604de864ac6ac2b1eb53ac440b8 |
| Source note | uspto-grants-2004_12 |