Sodium Hydroxide → (1Z, 3S)-1-bromo-4-(4-fluorophenoxy)-3-hydroxy-1-butene

Temperature

0 °C

AlCl3 (2.79 g, 21 mmol) was added in portions to a mixture of lithium aluminum hydride (LAH) (1.06 g, 28 mmol) and ether (70 mL). A solution of (3S)-1-bromo-4-(4-fluorophenoxy)-3-hydroxy-1-butyne (14 mmol) in ether (10 mL) was added cautiously. A vigorous reaction with evolution of gas was observed. The mixture was warmed to reflux on a water bath for 30 minutes. The reaction mixture was then cooled to 0° C. and treated with 2.8 mL water (slowly, vigorous reaction), 2.8 mL 15% NaOH, and finally 8.4 mL water. The resulting suspension was then stirred 10 minutes, filtered and the solids were washed with THF and ether. The solution was concentrated under vacuum to afford 2.94 g (81% yield for two steps) of (1Z, 3S)-1-bromo-4-(4-fluorophenoxy)-3-hydroxy-1-butene, a compound of formula (DD); 1H NMR (CDCl3) δ 2.41 (t, 1H), 3.85 (dd, 1H), 3.99 (dd, 1H), 4.50 (m, 1H), 6.31 (dd, 1H), 6.52 (dd, 1H), 6.83 (m, 2H), 6.97 (t, 2H) ppm.

1. customA vigorous reaction with evolution of gas
2. temperatureThe mixture was warmed
3. temperatureto reflux on a water bath for 30 minutes
4. filtrationfiltered
5. washthe solids were washed with THF and ether
6. concentrationThe solution was concentrated under vacuum

ORD record

ord-1d5082c1d2624ed79c2666eca6ae7c90

Source dataset

uspto-grants-2004_12

DOI

10.6084/m9.figshare.5104873.v1

Patent number

US06831186B2