2-[4-(Trifluoromethyl)phenyl]benzaldehyde → N-[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]-N-{[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]methyl}amine

HRID 2307627Notes

Reaction equation

HRID 2307627 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[C:10]([CH:15]=O)=[CH:11][CH:12]=[CH:13][CH:14]=2)=[CH:5][CH:4]=1.[C@@H:19]1([NH2:29])[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22][CH2:21][CH2:20]1>>[C@@H:19]1([NH:29][CH2:15][C:10]2[CH:11]=[CH:12][CH:13]=[CH:14][C:9]=2[C:6]2[CH:7]=[CH:8][C:3]([C:2]([F:18])([F:17])[F:1])=[CH:4][CH:5]=2)[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 27827102-[4-(Trifluoromethyl)phenyl]benzaldehydeHCID 70580741-Aminotetralin, (S)-

Product 1

HCID 69720991N-[(1S)-1,2,3,4-tetrahydro-1-naphthalenyl]-N-{[4'-(trifluoromethyl)[1,1'-biphenyl]-2-yl]methyl}amine

Procedure

4′-(Trifluoromethyl)[1,1′-biphenyl]-2-carbaldehyde and (1S)-1,2,3,4-tetrahydro-1-naphthalenylamine were processed as described in Example 1A to provide the title compound.

Sources & evidence

ORD record
ord-b8db3117e78d4fcebbd65c4a2aea9b5f
Source dataset
uspto-grants-2004_12
Patent number
US06831193B2

Reaction notes

Loading…