Potassium Phosphate, Tribasic → HCID 57763140, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 6-tert-butyl 1-ethyl 3-iodo-1H-pyrrolo[3,2-c]pyridine-1,6-dicarboxylate (55 mg, 0.13 mmol) and 4-nitrophenylboronic acid (67 mg, 0.4 mmol) in toluene (3 mL) and ethanol (1.5 mL), was added Pd(PPh3)4, followed by K3PO4 (2 M, 0.4 mL). The resulting mixture was purged with argon, and heated at 75-80° C. for 5 h. The desired product was purified by prep-HPLC to gave a yellow solid (8 mg, 18 % yield). 1H NMR (CDCl3) δ 8.68 (s, 1H), 8.30 (d, 2H, J=8.8 Hz), 8.00 (d, 1H, J=8.8 Hz), 7.36 (s, 1H), 7.25 (s, 1H), 1.51 (s,9H) ; LC-MS: m/z 284 (M-Bu)+.

Provenance & Evidence