4'-(Trifluoromethyl)-4-biphenylcarbaldehyde → HCID 69722952, compound

HRID 2307639Notes

Reaction equation

HRID 2307639 reaction equation
[F:1][C:2]([F:18])([F:17])[C:3]1[CH:8]=[CH:7][C:6]([C:9]2[CH:14]=[CH:13][C:12]([CH:15]=O)=[CH:11][CH:10]=2)=[CH:5][CH:4]=1.[C@@H:19]1([NH2:29])[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22][CH2:21][CH2:20]1>>[C@@H:19]1([NH:29][CH2:15][C:12]2[CH:13]=[CH:14][C:9]([C:6]3[CH:7]=[CH:8][C:3]([C:2]([F:18])([F:17])[F:1])=[CH:4][CH:5]=3)=[CH:10][CH:11]=2)[C:28]2[C:23](=[CH:24][CH:25]=[CH:26][CH:27]=2)[CH2:22][CH2:21][CH2:20]1

Participants

3

Reactant 2

HCID 27827124'-(Trifluoromethyl)-4-biphenylcarbaldehydeHCID 70580741-Aminotetralin, (S)-

Product 1

HCID 69722952HCID 69722952, compound

Procedure

4′-(Trifluoromethyl)[1,1′-biphenyl]-4-carbaldehyde and (1S)-1,2,3,4-tetrahydro-1-naphthalenylamine were processed as described in Example 1A to provide the title compound.

Sources & evidence

ORD record
ord-9b7ee47e10804121b45ce1c557821345
Source dataset
uspto-grants-2004_12
Patent number
US06831193B2

Reaction notes

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