Benzaldehyde, 3-(4-fluorophenoxy)- → HCID 69721502, compound

HRID 2307669Notes

Reaction equation

HRID 2307669 reaction equation
[F:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][C:7]2[CH:8]=[C:9]([CH:12]=[CH:13][CH:14]=2)[CH:10]=O)=[CH:4][CH:3]=1.[C@@H:17]1([NH2:27])[C:26]2[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=2)[CH2:20][CH2:19][CH2:18]1>>[F:1][C:2]1[CH:16]=[CH:15][C:5]([O:6][C:7]2[CH:8]=[C:9]([CH:12]=[CH:13][CH:14]=2)[CH2:10][NH:27][C@@H:17]2[C:26]3[C:21](=[CH:22][CH:23]=[CH:24][CH:25]=3)[CH2:20][CH2:19][CH2:18]2)=[CH:4][CH:3]=1

Participants

3

Reactant 2

HCID 3085320Benzaldehyde, 3-(4-fluorophenoxy)-HCID 70580741-Aminotetralin, (S)-

Product 1

HCID 69721502HCID 69721502, compound

Procedure

3-(4-Fluorophenoxy)benzaldehyde, prepared as described in Tanaka, et al., J. Med. Chem., 41 (1998) 4408-4420, and (1S)-1,2,3,4-tetrahydro-1-naphthalenylamine were processed as described in Example 1A to provide the title compound.

Sources & evidence

ORD record
ord-b674b9532e5a48f592b39ce4f8b01674
Source dataset
uspto-grants-2004_12
Patent number
US06831193B2

Reaction notes

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