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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 230773Generated: October 25, 2026

Picolyl chloride hydrochloride → Methyl 5-(pyridin-2-ylmethoxy)-1H-indole-2-carboxylate

https://huagongshe.com/reaction/230773

Reaction equation

Participants

RoleNameHCIDCharge
ReactantPicolyl chloride hydrochlorideHCID 23392—
Reactantmethyl 5-hydroxy-1H-indole-2-carboxylateHCID 21904362—
ProductMethyl 5-(pyridin-2-ylmethoxy)-1H-indole-2-carboxylateHCID 6899932018.1%

Reaction Steps

2-Chloromethylpyridine hydrochloride (515 mg) and methyl 5-hydroxy-1H-indole-2-carboxylate (600 mg) were processed in the same manner as in Production Example 1-1 to obtain the entitled compound (160 mg).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07566781B2
Source datasetuspto-grants-2009_07
ORD IDord-1300b71d4d044fc9aa10397a27f3c6f6
Source noteuspto-grants-2009_07