Acetic Anhydride → HCID 22607358, compound

Participants

Reaction Steps

A mixture of 3-bromo-5-hydroxypyridine (9.00 g, 51.7 mmol), acetic anhydride (6.0 mL) and triethylamine (12.0 mL) in THF (50 mL) was heated to reflux overnight, cooled to room temperature, diluted with diethyl ether, washed with water, 5% NaHCO3, water, and brine, dried (MgSO4), filtered, and concentrated to provide the desired product (9.37 g, 84%).

Provenance & Evidence