Hydrazine hydrate (1:1) → 6-Bromo-4-hydrazinylcinnoline

Participants

Reaction Steps

A solution of Example 34D (2.6 g, 10.6 mmol) in ethanol (70 mL) was treated with hydrazine monohydrate (3 mL, 90% solution), stirred at room temperature for 3 days, and filtered. The solid washed with water (50 mL) and diethyl ether (50 mL) and dried under vacuum to provide the desired product (2.5 g, 100%).

Provenance & Evidence