反应详情

A methanol solution (100 mL) of 1-pyridin-2-ylethanone (10.0 g) was cooled to 0° C., sodium borohydride (6.2 g) was added thereto and stirred at that temperature for 4 hours. Then water was added to the reaction solution, and the organic solvent was evaporated off under reduced pressure. The resulting residue was extracted with ethyl acetate. The organic layer was dried with anhydrous magnesium sulfate, and the solvent was evaporated off under reduced pressure. The resulting residue was purified through silica gel column chromatography (hexane/ethyl acetate=4/1 to 3/2) to obtain the entitled compound (9.0 g).

1. customthe organic solvent was evaporated off under reduced pressure
2. extractionThe resulting residue was extracted with ethyl acetate
3. dry with materialThe organic layer was dried with anhydrous magnesium sulfate
4. customthe solvent was evaporated off under reduced pressure
5. customThe resulting residue was purified through silica gel column chromatography (hexane/ethyl acetate=4/1 to 3/2)