HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrazine → (1S)-[2-[5-(3-amino-1h-indazol-5-yl)-pyridin-3-yloxy]-1-(1h-indol-3-ylmethyl)-ethyl]-carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrazine | HCID 9321 | — |
| Reactant | HCID 69919336 | HCID 69919336 | — |
| Solvent | Sodium chloride; water | HCID 57417360 | — |
| Product | (1S)-[2-[5-(3-amino-1h-indazol-5-yl)-pyridin-3-yloxy]-1-(1h-indol-3-ylmethyl)-ethyl]-carbamic acid tert-butyl ester | HCID 69918281 | 84% |
Reaction Steps
A mixture of Example 97B (120 mg, 0.25 mmol) and 98% hydrazine (5 mL) was heated to reflux for 5 hours, poured over ice, diluted with brine, extracted with ethyl acetate, dried over MgSO4, and concentrated. Purification by flash chromatography (7% MeOH/CH2Cl2) provided the desired product (103 mg, 84%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06831175B2 |
| Source dataset | uspto-grants-2004_12 |
| ORD ID | ord-4b3846b4e4254f81a62d45e29aa6dd96 |
| Source note | uspto-grants-2004_12 |