Sodium Methoxide → HCID 69918577, compound

HRID 2307798Notes

Reaction equation

HRID 2307798 reaction equation
[C:1]([O:5][C:6](=[O:36])[NH:7][C@@H:8]([CH2:26][C:27]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[NH:29][CH:28]=1)[CH2:9][O:10][C:11]1[CH:12]=[N:13][CH:14]=[C:15]([CH:17]=[CH:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21](F)[CH:20]=2)[CH:16]=1)([CH3:4])([CH3:3])[CH3:2].[CH3:37][O-:38].[Na+]>CO>[C:1]([O:5][C:6](=[O:36])[NH:7][C@@H:8]([CH2:26][C:27]1[C:35]2[C:30](=[CH:31][CH:32]=[CH:33][CH:34]=2)[NH:29][CH:28]=1)[CH2:9][O:10][C:11]1[CH:12]=[N:13][CH:14]=[C:15]([CH:17]=[CH:18][C:19]2[CH:24]=[CH:23][N:22]=[C:21]([O:38][CH3:37])[CH:20]=2)[CH:16]=1)([CH3:4])([CH3:3])[CH3:2]

Participants

4

Reactant 2

HCID 10942334Sodium MethoxideHCID 69917639HCID 69917639, compound

Product 1

HCID 69918577HCID 69918577, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

A mixture of Example 216B (100 mg, 0.2 mmol), NaOMe (25% in MeOH) (1 mL) in MeOH (10 mL) was refluxed for 8 hrs. The mixture was concentrated to give the crude product.

Workup

  1. concentrationThe mixture was concentrated

Sources & evidence

ORD record
ord-a25b5edf60384a3d9dcbb6303bd0431d
Source dataset
uspto-grants-2004_12
Patent number
US06831175B2

Reaction notes

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