Tetrabutylammonium Fluoride → 1h-Pyrazolo[3,4-b]pyridine-1-carboxylic acid,5-hydroxy-3-(4-pyridinyl)-,1,1-dimethylethyl ester

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Reaction Steps

A mixture of Example 232C (91 mg, 0.213 mmol) and TBAF (1 in THF, 213 μL, 0.213 mmol) in THF (10 mL) was stirred at rt for 5 min. Reaction was concentrated. Flash column chromatography eluting with 5% methanol/CH2Cl2 to give the dedired product purified the residue (75%).

Provenance & Evidence