Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | Acetamidine | HCID 67171 | — |
| Reactant | 4-Bromo-2-fluorobenzaldehyde | HCID 143517 | — |
| Solvent | Dimethylacetamide | HCID 31374 | — |
| Product | 7-Bromo-2-methylquinazoline | HCID 22607818 | 4% |
Reaction Steps
The 4-Bromo-2-fluoro-benzaldehyde (1 g, 4.9 mmol), acetamidine and DMA were mixed and heated to 140° C. for 5 hours. The mixture was cooled to room temperature and dried under vacuum. The mixture was purified by flash column afforded 47 mg product in 4% yield. MS (ESI) m/e 223 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06831175B2 |
|---|
| Source dataset | uspto-grants-2004_12 |
|---|
| ORD ID | ord-0e53fc394a054dc2b1c292595095782c |
|---|
| Source note | uspto-grants-2004_12 |
|---|
