HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → methyl 1H-indazole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Methanol | HCID 887 | — |
| Reactant | Indazole-3-carboxylic acid | HCID 78250 | — |
| Product | methyl 1H-indazole-3-carboxylate | HCID 657476 | — |
Reaction Steps
A solution of 3-carboxyindazole (2.0 g; 12.3 mmol) and conc.HCl (2 mL) in MeOH (50 mL) was heated at reflux overnight, concentrated, diluted with 2N NaOH (aq), and extracted with EtOAc. The extracts were rinsed with brine, dried (MgSO4), and concentrated to provide the desired product.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06831175B2 |
| Source dataset | uspto-grants-2004_12 |
| ORD ID | ord-31d8f367d1474c649b8a89c6657acb97 |
| Source note | uspto-grants-2004_12 |