HuagongsheHuagongshe Chemistry Print Report · For research reference only
Iodine → Methyl 5-iodo-1H-indazole-3-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Iodine | HCID 807 | — |
| Reactant | methyl 1H-indazole-3-carboxylate | HCID 657476 | — |
| Reactant | Bistrifluoroacetoxyiodobenzene | HCID 12041285 | — |
| Reactant | Sodium Bisulfite | HCID 23665763 | — |
| Solvent | Dichloromethane | HCID 6344 | — |
| Product | Methyl 5-iodo-1H-indazole-3-carboxylate | HCID 12689370 | 36% |
Reaction Steps
A solution of Example 271A (300 mg; 1.7 mmol), bis(trifluoroacetoxy)iodobenzene (800 mg; 1.9 mmol), and iodine (253 mg; 1.0 mmol) in CH2Cl2 (10 mL) was stirred overnight at r.t., and treated with sodium bisulfite (aq). The precipitate was collected, rinsed with water and hexane, and dried under vacuum to provide the desired product (180 mg; 36%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06831175B2 |
| Source dataset | uspto-grants-2004_12 |
| ORD ID | ord-6a826437bbbf4e1a8ae6e74207f3e971 |
| Source note | uspto-grants-2004_12 |