HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Naphthalenesulfonyl chloride → HCID 69919218, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Naphthalenesulfonyl chloride | HCID 7125 | — |
| Reactant | [2-(5-Isoquinolin-6-yl-pyridin-3-ylamino)-ethyl]-carbamic acid tert-butyl ester | HCID 69918479 | — |
| Solvent | Pyridine | HCID 1049 | — |
| Product | HCID 69919218 | HCID 69919218 | 65% |
Reaction Steps
To a solution of Example 386B (70 mg, 0.192 mmol) in pyridine (3 mL) was added 2-naphthalenesulfonyl chloride (87 mg, 0.384 mmol) at rt. The formed yellow solution was stirred at rt for 15 h. Pyridine was removed under reduced pressure and the residual oil was purified by flash chromatography (0-15% CH3OH in 2:1 EtOAc/hexane) to provide the desire product (69 mg, 65%). MS (APCI) m/z 555 (M+1)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06831175B2 |
| Source dataset | uspto-grants-2004_12 |
| ORD ID | ord-9663016458654aea89adebbba26e3f35 |
| Source note | uspto-grants-2004_12 |