tert-Butoxy bis(dimethylamino)methane → HCID 53929931, compound

HRID 2307848Notes

Reaction equation

HRID 2307848 reaction equation
[CH:1]1([CH2:4][C:5]#[N:6])[CH2:3][CH2:2]1.[CH3:7][N:8]([CH:10](N(C)C)OC(C)(C)C)[CH3:9]>>[CH:1]1([C:4](=[CH:7][N:8]([CH3:10])[CH3:9])[C:5]#[N:6])[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 79885tert-Butoxy bis(dimethylamino)methaneHCID 643447Cyclopropylacetonitrile

Product 1

HCID 53929931HCID 53929931, compound

Procedure

At 100° C., 25 g (292.8 mmol) of cyclopropylacetonitrile (obtainable by the process described in U.S. Pat. No. 3,454,575) and 25.5 g (30.2 ml, 146.4 mmol) of bis(dimethylamino)-tert-butyloxymethane are stirred under a riser pipe for 46 hours. Volatile components are evaporated under reduced pressure and the residue is subsequently distilled at 0.1 Torr and 60-65° C.

Workup

  1. customAt 100° C.
  2. customVolatile components are evaporated under reduced pressure
  3. distillationthe residue is subsequently distilled at 0.1 Torr and 60-65° C.

Sources & evidence

ORD record
ord-588d68e56d994545846359bbe9d6e608
Source dataset
uspto-grants-2004_12
Patent number
US06833364B1

Reaction notes

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