Ammonia → 1-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide

HRID 2307849Notes

Reaction equation

HRID 2307849 reaction equation
[F:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[CH2:4][N:5]1[C:9]2=[N:10][CH:11]=[CH:12][CH:13]=[C:8]2[C:7]([C:14](OCC)=[O:15])=[N:6]1.[NH3:23]>CO>[F:1][C:2]1[CH:22]=[CH:21][CH:20]=[CH:19][C:3]=1[CH2:4][N:5]1[C:9]2=[N:10][CH:11]=[CH:12][CH:13]=[C:8]2[C:7]([C:14]([NH2:23])=[O:15])=[N:6]1

Participants

4

Reactant 2

HCID 222AmmoniaHCID 111623453-Ethoxycarbonyl-1-(2-fluorbenzyl)-1H-pyrazolo-(3,4,5)-pyridin

Product 1

HCID 113231781-(2-Fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carboxamide

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

10.18 g (34 mmol) of the ester obtained in Example IV are initially charged in 150 ml of methanol which has been saturated with ammonia at 0-10° C. The mixture is stirred at room temperature for two days and subsequently concentrated under reduced pressure.

Workup

  1. concentrationsubsequently concentrated under reduced pressure

Sources & evidence

ORD record
ord-9079c4ee8c1640e6b2454999168d8143
Source dataset
uspto-grants-2004_12
Patent number
US06833364B1

Reaction notes

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