HuagongsheHuagongshe Chemistry Print Report · For research reference only
Sodium Methoxide → Methyl 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbiMidate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Sodium Methoxide | HCID 10942334 | — |
| Reactant | 1-((2-Fluorophenyl)methyl)pyrazolo(3,4-b)pyridine-3-carbonitrile | HCID 11402500 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | Methyl 1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine-3-carbiMidate | HCID 11243078 | — |
Reaction Steps
30.37 g (562 mmol) of sodium methoxide are dissolved in 1.5 l of methanol, and 36.45 g (144.5 mmol) of 3-cyano-1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridine (from Example VII) are added. The mixture is stirred at room temperature for 2 hours and the resulting solution is used directly for the next step.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06833364B1 |
| Source dataset | uspto-grants-2004_12 |
| ORD ID | ord-24c1f83c07a84496acfcafccbe288eeb |
| Source note | uspto-grants-2004_12 |