2-Chloro-5-iodopyridine → HCID 86759579, compound

HRID 2307862Notes

Reaction equation

HRID 2307862 reaction equation
[CH3:1][C@H:2]1[CH2:7][CH2:6][NH:5][CH2:4][C@H:3]1[NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12].[Cl:16][C:17]1[CH:22]=[CH:21][C:20](I)=[CH:19][N:18]=1>>[Cl:16][C:17]1[N:18]=[CH:19][C:20]([N:5]2[CH2:6][CH2:7][C@@H:2]([CH3:1])[C@H:3]([NH:8][C:9](=[O:15])[O:10][C:11]([CH3:14])([CH3:13])[CH3:12])[CH2:4]2)=[CH:21][CH:22]=1

Participants

3

Reactant 2

HCID 43971762-Chloro-5-iodopyridineHCID 450921921,1-Dimethylethyl N-[(3S,4S)-4-methyl-3-piperidinyl]carbamate

Product 1

HCID 86759579HCID 86759579, compoundYield 24.4%

Procedure

The trans product from Example 39C (0.146 g, 0.68 mmol) and 2-chloro-5-iodopyridine (0.21 g, 0.88 mmol; Aldrich) were processed according to the procedure in Example 1A to provide the title compound (0.054 g, 24%). MS (CI/NH3) m/z 326/328 (M+H)+.

Sources & evidence

ORD record
ord-877290b43aa6455a996b1aff48727dd8
Source dataset
uspto-grants-2004_12
Patent number
US06833370B1

Reaction notes

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