3-Aminoazetidine, 3-BOC protected → HCID 53638023, compound

HRID 2307864Notes

Reaction equation

HRID 2307864 reaction equation
[NH:1]1[CH2:4][CH:3]([NH:5][C:6](=[O:12])[O:7][C:8]([CH3:11])([CH3:10])[CH3:9])[CH2:2]1.[Cl:13][C:14]1[CH:19]=[CH:18][C:17](I)=[CH:16][N:15]=1>>[Cl:13][C:14]1[N:15]=[CH:16][C:17]([N:1]2[CH2:4][CH:3]([NH:5][C:6](=[O:12])[O:7][C:8]([CH3:9])([CH3:11])[CH3:10])[CH2:2]2)=[CH:18][CH:19]=1

Participants

3

Reactant 2

HCID 15194053-Aminoazetidine, 3-BOC protectedHCID 43971762-Chloro-5-iodopyridine

Product 1

HCID 53638023HCID 53638023, compoundYield 47%

Procedure

tert-Butyl 3-azetidinylcarbamate (0.70 g, 4.0 mmol) and 2-chloro-5-iodopyridine (1.46 g, 6.0 mmol; Aldrich) were processed according to the procedure described in Example 1A to provide the title compound (0.53 g, 47%). MS (CI/NH3) m/z 284/286.

Sources & evidence

ORD record
ord-99723ac2114a42599f29d938acb1576d
Source dataset
uspto-grants-2004_12
Patent number
US06833370B1

Reaction notes

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