5-Chloromethyl-4-methyl-2-(4-trifluoromethyl-phenyl)-thiazole → HCID 20745829, compound

HRID 2307881Notes

Reaction equation

HRID 2307881 reaction equation
Cl[CH2:2][C:3]1[S:7][C:6]([C:8]2[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=2)=[N:5][C:4]=1[CH3:18].[CH3:19][O:20][C:21](=[O:35])[CH2:22][O:23][C:24]1[C:32]([CH3:33])=[CH:31][C:30]([SH:34])=[C:29]2[C:25]=1[CH2:26][CH2:27][CH2:28]2>>[CH3:19][O:20][C:21](=[O:35])[CH2:22][O:23][C:24]1[C:32]([CH3:33])=[CH:31][C:30]([S:34][CH2:2][C:3]2[S:7][C:6]([C:8]3[CH:13]=[CH:12][C:11]([C:14]([F:17])([F:16])[F:15])=[CH:10][CH:9]=3)=[N:5][C:4]=2[CH3:18])=[C:29]2[C:25]=1[CH2:26][CH2:27][CH2:28]2

Participants

3

Reactant 2

HCID 27830065-Chloromethyl-4-methyl-2-(4-trifluoromethyl-phenyl)-thiazoleHCID 69469295HCID 69469295, compound

Product 1

HCID 20745829HCID 20745829, compound

Procedure

The title compound was prepared from 5-(chloromethyl)-4-methyl-2-[4-(trifluoromethyl)phenyl]-1,3-thiazole and (7-mercapto-5-methyl-indan-4-yloxy)-acetic acid methyl ester (prepared in a similar manner as described for Example 1D) in a manner analogous to Example 1E. MS m/z 508 (M+1).

Workup

  1. customprepared in a similar manner

Sources & evidence

ORD record
ord-a30cea7230bd4178b608c310511a38c8
Source dataset
uspto-grants-2004_12
Patent number
US06833380B2

Reaction notes

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