HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide → Methyl 3-methylthio-2-acetamidocinnamate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide | HCID 6228 | — |
| Reactant | Methyl 2-acetamidoacrylate | HCID 98644 | — |
| Reactant | Sodium Bicarbonate | HCID 516892 | — |
| Reactant | 3-Iodothioanisole | HCID 10705783 | — |
| Catalyst | Tetrabutylammonium Chloride | HCID 70681 | — |
| Catalyst | palladium(II) acetate | HCID 167845 | — |
| Product | Methyl 3-methylthio-2-acetamidocinnamate | HCID 54544409 | — |
Reaction Steps
4.8 g of methyl (3-methylthio)-2-acetamidocinnamate are obtained in the form of a white solid which melts at 139° C. by proceeding as in Example 34-3 but using 5.6 g of methyl 2-acetamidoacrylate, 0.18 g of palladium acetate, 8.2 g of tetrabutylammonium chloride, 5.86 g of sodium hydrogen carbonate and 6.5 g of 3-iodo-1-methylthiobenzene dissolved in 160 ml of anhydrous DMF.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06833382B2 |
| Source dataset | uspto-grants-2004_12 |
| ORD ID | ord-edd9731b18df44c79ff3ba6129fcc325 |
| Source note | uspto-grants-2004_12 |