Hydrochloric Acid → HCID 178526249, compound

Participants

Reaction Steps

2-(5-hydroxypentylamino)pyridine N-oxide was prepared dissolving 2-chloropyridine N-oxide.HCl (18.07 mmol), 5-amino-1-pentanol (36.14 mmol), and NaHCO3 (90.36 mmol) in tert-amyl alcohol (20 mL), then refluxing overnight under Ar. After cooling, the reaction was filtered and concentrated to a green oil. Purification by silica gel chromatography (eluent: 94:5:1 CH2Cl2, MeOH, NH4OH) yielded a yellow solid (3.07 g). 1H NMR was consistent with the desired product.

Provenance & Evidence