反应详情

A mixture of 2-chloro-4-(1-ethyl-propylamino)-6-methyl-nicotinic acid methyl ester, trimethylaniline, potassium carbonate, copper in DMF was heated at reflux. The mixture was quenched with ammonium chloride and stirred for 20 min, filtered through celite and washed with ethyl acetate. The filtrate was extracted with ethyl acetate. The organic layer was separated, dried and concentrated to dryness. The residue was purified through silica gel column chromatography using 2% methanol in chloroform as eluent to give the title compound as a solid.

1. temperaturewas heated
2. temperatureat reflux
3. customThe mixture was quenched with ammonium chloride
4. filtrationfiltered through celite
5. washwashed with ethyl acetate
6. extractionThe filtrate was extracted with ethyl acetate
7. customThe organic layer was separated
8. customdried
9. concentrationconcentrated to dryness
10. customThe residue was purified through silica gel column chromatography