HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2308001Generated: November 3, 2026
L-Methioninol → 2-(4-Chloro-2,6-dimethyl-phenoxy)-4-(1-hydroxymethyl-3-methylsulfanyl-propylamino)-6-methyl-nicotinic acid methyl ester
https://huagongshe.com/reaction/2308001
Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | L-Methioninol | HCID 2724404 | — |
| Reactant | 2-(4-Chloro-2,6-dimethyl-phenoxy)-4-chloro-6-methyl-nicotinic acid methyl ester | HCID 24806260 | — |
| Product | 2-(4-Chloro-2,6-dimethyl-phenoxy)-4-(1-hydroxymethyl-3-methylsulfanyl-propylamino)-6-methyl-nicotinic acid methyl ester | HCID 69587900 | — |
Reaction Steps
A mixture of 2-(4-chloro-2,6-dimethyl-phenoxy)-4-chloro-6-methyl-nicotinic acid methyl ester and L-methioninol in N-methyl-2-pyrodone (NMP) was heated in a 134° C. oil bath for 3 hr. Standard work-up procedure and purification provided the title compound. 1H NMR(CDCl3) d 8.25(d,1H), 7.02(s,2H), 6.30(s,1H), 3.85(s,3H), 3.6-3.9(m,3H), 2.5-2.7(m,2H), 2.14(s,3H), 2.10(s,3H), 2.06(s,6H), 1.8-2.1 (m,2H)ppm.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patent number | US06833378B2 |
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| Source dataset | uspto-grants-2004_12 |
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| ORD ID | ord-0fd7e410e2a14b64b5402202c5282bb3 |
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| Source note | uspto-grants-2004_12 |
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