HCID 86584332, compound → HCID 69900893, compound

Participants

Reaction Conditions

Reaction Steps

To a solution of MeMgBr in dry THF was added a solution of 2-(4-chloro-2,6-dimethyl-phenoxy)-4-(1-formyl-propylamino)-6-methyl-nicotinamide in dry THF at −78° C. The mixture was stirred at −78° C. for 2 hr, then quenched with dilute acid. After standard extraction and purification, the title compound was obtained. 1H NMR(CDCl3) d 9.8(d,1H), 7.9(nbrs,1H), 7.05(s,2H), 6.27(s,0.5H), 6.24(s,0.5H), 5.6(brs,1H), 3.91(m,0.5H), 3.89(m,0.5H), 3.51(m,0.5H), 3.3(m,0.5H), 2.09(s,9H), 1.5-1.8(m,2H), 1.26(d,3H), 0.98(t,3H) ppm.

Provenance & Evidence