3,3-Difluoropyrrolidine → N-{2-[3-(3,3-difluoropyrrolidin-1-yl)propyl]-3-methylimidazo[1,2-a]pyridin-6-yl}-4-(pyridin-2-ylmethoxy)benzamide

Participants

Role	Name	HCID	Charge
Reactant	3,3-Difluoropyrrolidine	HCID 2782827	—
Reactant	N-[2-(3-hydroxypropyl)-3-methylimidazo[1,2-a]pyridin-6-yl]-4-(pyridin-2-ylmethoxy)benzamide	HCID 57763130	—
Product	N-{2-[3-(3,3-difluoropyrrolidin-1-yl)propyl]-3-methylimidazo[1,2-a]pyridin-6-yl}-4-(pyridin-2-ylmethoxy)benzamide	HCID 57763093	36.8%

Reaction Steps

The compound (25.0 mg) obtained in Example 14 and 3,3-difluoropyrrolidine (3.4 mg) were processed in the same manner as in Example 19 to obtain the entitled compound (5.9 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07566781B2
Source dataset	uspto-grants-2009_07
ORD ID	ord-9a2d11778e2e4a8aa993ecf1db05474b
Source note	uspto-grants-2009_07