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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2308061Generated: November 2, 2026

Sodium → (Z)-3-methoxy-4-hydroxystyryl-2-chloro-4-fluorobenzylsulfide

https://huagongshe.com/reaction/2308061

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodiumHCID 5360545—
Reactant3-Methoxy-4-hydroxyphenylacetyleneHCID 12301242—
Reactant(2-chloro-4-fluorophenyl)methanethiolHCID 22026132—
Product(Z)-3-methoxy-4-hydroxystyryl-2-chloro-4-fluorobenzylsulfideHCID 86593400—

Reaction Steps

A solution of 3-methoxy-4-hydroxyphenylacetylene (0.02 mol), 2-chloro-4-fluorobenzyl mercaptan (0.02 mol) and metallic sodium (0.02 g atom) is subjected to the General Procedure to form (Z)-3-methoxy-4-hydroxystyryl-2-chloro-4-fluorobenzylsulfide. The title compound is obtained following oxidation of the sulfide, according to the General Procedure.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06833480B2
Source datasetuspto-grants-2004_12
ORD IDord-4938cb35b73048f88aff242a3cf7d49e
Source noteuspto-grants-2004_12