Hydrochloric Acid → 5-(2-[1-methyl-1H-imidazol-2-yl]thieno[3,2-b]pyridin-7-ylamino)-2-methylindole-1-carboxylic acid methylamide

Participants

Reaction Steps

To a stirred slurry of 5-amino-2-methylindole-1-carboxylic acid methylamide (632 mg, 3.1 mmole), prepared in Example 1(a) step (iii), in 2-propanol (35 ml) was added 4.0 M HCl in 1,4-dioxane (0.75 ml, 3 mmole) followed by 7-chloro-2-(1-methyl-1H-imidazol-2-yl)thieno[3,2-b]pyridine (500 mg, 2 mmole), prepared as described in PCT application WO-99/24440, Example 149. The resultant solution was heated at reflux for 54 hours. After cooling to room temperature, the crude reaction mixture was poured into sat'd NaHCO3 (150 ml), then diluted with water (50 ml). The precipitate that formed was collected by filtration, then washed with water (2×50 ml) and EtOAc (3×30 ml). The solid obtained was suspended in EtOAc (15 ml), filtered and washed with Et2O (3×10 ml) to give 693 mg (83%) of a beige solid. 1H NMR (DMSO-d6): δ 8.76 (1H, s), 8.22 (1H, d, J=5.5 Hz), 8.20 (1H, q, J=5.4 Hz), 7.68 (1H, s), 7.60 (1H, d, J=8.7 Hz), 7.35 (1H, d, J=0.2 Hz), 7.34 (1H, d, J=1.9Hz), 7.08 (1H, dd, J=1.9, 8.7Hz), 6.98 (1H, d, J=0.2 Hz), 6.67 (1H, d, J=5.5Hz), 6.36 (1H, s), 3.94 (3H, s), 2.88 (3H, d, J=5.4 Hz), 2.48 (3H, s). Anal. Calcd. for C22H20N6OS.1.0H2O: C, 60.81; H, 5.10; N, 19.34; S, 7.38. Found: C, 60.53; H, 5.13; N, 19.07; S, 7.50.

Provenance & Evidence