HCID 60128540, compound → (3R,4S)-3,4-Dimethoxypyrrolidine

Participants

Reaction Steps

To a stirred solution of 3,4-cis-dimethoxy-pyrrolidine-1-carboxylic acid benzyl ester (16.95 g, 63.88 mmol) in 150 mL MeOH was added 1.3 g Pd on C (10% w/w). The mixture was stirred under H2 balloon at room temperature for 3 hours and filtered through celite. The filtrate was concentrated in vacuo, re-dissolved in CH2Cl2 and dried over Na2SO4. The solution was concentrated to give 8.3 g product as yellow oil (99% yield). 1H NMR (300 MHz, CDCl3) δ 3.80 (m, 2H), 3.47 (bs, 2H), 3.41 (s, 6H), 3.01 (bs, 2H).

Provenance & Evidence