Methyl iodide → HCID 60128538, compound

Participants

Reaction Steps

To a solution of benzyl (3R,4R)-3,4-dihydroxypyrrolidine-1-carboxylate (3.81 g, 16.1 mmol) in 60 mL THF was added NaH (0.803 g, 20.07 mmol). The reaction mixture was stirred at room temperature for 15 min, CH3I (2.0 mL, 32.2 mmol) was added and stirred at room temperature overnight. The reaction mixture was quenched with H2O (80 mL) and extracted with EtOAc (2×100 mL). The organic layer was dried and concentrated. The residue was purified by flash column chromatography (1˜2% CH3OH in CH2Cl2) to give a white solid (1.12 g, 28%). 1H NMR (CDCl3) δ 7.36-7.29 (5H, m), 5.12 (2H, s), 4.28-4.27 (1H, m), 3.72-3.37 (5H, m), 3.35 (3H, s), 1.95-1.89 (1H, m). ESIMS (MH+): 252.05.

Provenance & Evidence