Ammonium Chloride → HCID 86759583, compound

Participants

Reaction Steps

0.997 g (1.00 mmol) 3,5-Dinitrobenzoic acid 11-[2-[6-[2-methoxy-4-(methoxycarbonylvinyl)phenoxy]oxyhexyl]-5-[4-(2-methoxycarbonylvinyl)benzoyloxy]benzoyloxy]undecyl ester and 0 g (4.00 mmol) of ammonium chloride were suspended in 15 ml of a mixture consisting of methanol:water 9:1. 1.31 g (20.0 mmol) of zinc was then added in one portions. After 0.5 hour at room temperature 20 ml of a mixture consisting of methanol:water 9:1 is added to the thick suspension. After a further 21 hours the reaction suspension was partitioned between dichloromethane and water. The resulting suspension was filtered, the organic phase was washed with a saturated sodium bicarbonate solution and repeatedly with water. The organic phase was then dried over sodium sulfate, filtered and concentrated by evaporation. Chromatography of the residue on silica yield 3,5-Diaminobenzoic acid 11-[2-[6-[2-methoxy-4-(methoxycarbonylvinyl)phenoxy]oxyhexyl]-5-[4-(2-methoxycarbonylvinyl)benzoyloxy]benzoyloxy]undecyl ester.

Provenance & Evidence