Methacrylic Acid → HCID 18329199, compound

Participants

Reaction Steps

2.56 g (30 mmol) of methacrylic acid in 10 ml of THF were slowly added dropwise to a solution of 6 g (27 mmol) of (E)-3-[4-[2-hydroxyethoxy]phenyl]acrylic acid methyl ester, 5.85 g (28.3 mmol) of N,N′-dicyclohexylcarbodiimide (DCC) and 0.37 g (3 mmol) of 4-dimethylamino-pyridine in 80 ml of tetrahydrofuran (THF). The batch was stirred at room temperature overnight. In order to complete the reaction there were added firstly a further 1.46 g (7.1 mmol) of DCC and, after stirring for one hour, a further 0.5 g (5.9 mmol) of methacrylic acid. The batch was stirred for a further 24 hours, filtered and the filtrate was extracted 3 times each time with 200 ml of 5% acetic acid and 200 ml of water. The ether phase was dried over Na2SO4, evaporated and the residue was recrystallized from cyclohexane. Subsequently, the still slightly impure product was filtered over a thin silica gel layer (eluent:diethyl ether/hexane=1:1). This gave 8.3 g of 2-methylacrylic acid 2-[4-[(E)-2-(methoxycarbonyl)vinyl]phenoxy]ethyl ester as a white powder with a melting point of 81-82° C. and an absorption maximum of λmax. (in CH2Cl2)=306.5 nm (ε=23675 l/mmol cm).

Provenance & Evidence