Potassium Carbonate → HCID 21044146, compound

Participants

Reaction Steps

2-Chloroquinoline (1.20 g, 12.2 mmol), 2,4-difluorophenylboronic acid (2.32 g, 14.7 mmol), were added to 10 mL of ethylene glycol dimethyl ether (DME) and 12 mL of a 2 M solution of potassium carbonate. Triphenylphosphine (0.32 g, 1.2 mmol) and palladium acetate (0.069 g, 0.3 mmol) were added to the stirred reaction mixture and refluxed for 17 hours under a nitrogen atmosphere. The mixture was cooled to room temperature and the aqueous phase was separated from the organic phase. The aqueous phase was extracted with 2×30 mL of ethyl acetate. The combined organic extracts were washed first with distilled water followed by brine. The solvent was dried over magnesium sulfate and concentrated to give 2-(2,4-difluorophenyl)quinoline (2.9 g, 98.6%) as a white solid.

Provenance & Evidence