Participants
| Role | Name | HCID | Charge |
|---|
| Reactant | 2-Methylimidazole | HCID 12749 | — |
| Reactant | 1-Benzylpiperazine | HCID 75994 | — |
| Reactant | 2,4-Dichloro-6-methyl-5-nitropyrimidine | HCID 275294 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | HCID 9908568 | HCID 9908568 | — |
Reaction Steps
To a solution of 2,4dichloro-6-methyl-5-nitropyrimidine (175 mg, 0.84 mmol) in dioxane (5 mL) at 80° C. was added 2-methylimidazole (85 mg, 0.84 mmol) and 1-benzylpiperazine (148 μL, 0.84 mmol). The solution was stirred overnight at 80° C., cooled, and directly chromatographed (1/1 hexane diethyl ether) to yield the title compound (u).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| Patent number | US06835726B2 |
|---|
| Source dataset | uspto-grants-2004_12 |
|---|
| ORD ID | ord-64f3b9e2a77a4e8ba48e754f3c17eb8c |
|---|
| Source note | uspto-grants-2004_12 |
|---|
