反应详情

To anhydrous dimethylformamide solution (10 ml) containing 2,4-dioxopyrimidine (1.0 g) are added benzyl bromoacetate (2.5 g) and potassium carbonate (2.5 g), and the mixture is stirred at room temperature for 15 hours. The reaction solution is poured into water, and the mixture is extracted with ethyl acetate. The extract is washed with a saturated brine, and dried over anhydrous magnesium sulfate. The solvent is removed by evaporation under reduced pressure, and the precipitated crystals are washed with diethyl ether to give the desired 1-benzyloxycarbonylmethyl-2,4-dioxopyrimidine (1.4 g) as colorless crystals.

1. extractionthe mixture is extracted with ethyl acetate
2. washThe extract is washed with a saturated brine
3. dry with materialdried over anhydrous magnesium sulfate
4. customThe solvent is removed by evaporation under reduced pressure
5. washthe precipitated crystals are washed with diethyl ether