3-Bromoaniline → HCID 10201097, compound

HRID 2308195Notes

Reaction equation

HRID 2308195 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]3[O:15][CH2:14][CH:13]([CH2:16][O:17][CH3:18])[O:12][C:9]=3[CH:10]=2)[N:5]=[CH:4][N:3]=1.[Br:19][C:20]1[CH:21]=[C:22]([CH:24]=[CH:25][CH:26]=1)[NH2:23]>>[Br:19][C:20]1[CH:21]=[C:22]([NH:23][C:2]2[C:11]3[C:6](=[CH:7][C:8]4[O:15][CH2:14][CH:13]([CH2:16][O:17][CH3:18])[O:12][C:9]=4[CH:10]=3)[N:5]=[CH:4][N:3]=2)[CH:24]=[CH:25][CH:26]=1

Participants

3

Reactant 2

HCID 115623-BromoanilineHCID 111614544-Chloro-7-methoxy methyl-[1,4]dioxano[2,3-g]quinazoline

Product 1

HCID 10201097HCID 10201097, compoundYield 63%

Procedure

The titled compound (25 mg, 63%, m.p. 268-274° C.) was prepared in a similar manner as in Example 8, except for employing 4-chloro-7-methoxymethyl-[1,4]dioxano[2,3-g]quinazoline (30 mg, 0.113 mmol) and 3-bromoaniline (39 mg, 0.226 mmol).

Sources & evidence

ORD record
ord-b20628cdec084bb3b7b733d39784abec
Source dataset
uspto-grants-2004_12
Patent number
US06835735B2

Reaction notes

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