3-Chloro-4-methylaniline → HCID 20747409, compound

HRID 2308200Notes

Reaction equation

HRID 2308200 reaction equation
Cl[C:2]1[C:11]2[C:6](=[CH:7][C:8]3[O:15][CH2:14][CH:13]([CH2:16][O:17][CH3:18])[O:12][C:9]=3[CH:10]=2)[N:5]=[CH:4][N:3]=1.[Cl:19][C:20]1[CH:21]=[C:22]([CH:24]=[CH:25][C:26]=1[CH3:27])[NH2:23]>>[Cl:19][C:20]1[CH:21]=[C:22]([NH:23][C:2]2[C:11]3[C:6](=[CH:7][C:8]4[O:15][CH2:14][CH:13]([CH2:16][O:17][CH3:18])[O:12][C:9]=4[CH:10]=3)[N:5]=[CH:4][N:3]=2)[CH:24]=[CH:25][C:26]=1[CH3:27]

Participants

3

Reactant 2

HCID 72553-Chloro-4-methylanilineHCID 111614544-Chloro-7-methoxy methyl-[1,4]dioxano[2,3-g]quinazoline

Product 1

HCID 20747409HCID 20747409, compoundYield 49%

Procedure

The titled compound (54 mg, 49%) was prepared in a similar manner as in Example 8, except for employing 4-chloro-7-methoxymethyl-[1,4]dioxano[2,3-g]quinazoline (80 mg, 0.3 mmol) and 3-chloro-4-methylaniline (84 mg, 0.6 mmol).

Sources & evidence

ORD record
ord-b93c5169d5e543e693e2f2acbebe4741
Source dataset
uspto-grants-2004_12
Patent number
US06835735B2

Reaction notes

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