Trimethylamine → HCID 69898250, compound

Participants

Reaction Steps

3 ml of trimethylamine was mixed with the titled compound of Example 45 (40 mg, 0.075 mmol), 1-trimethylsilylacetylene (15 mg, 0.15 mmol), copper iodide (16 mg, 0.084 mmol) and tetrakis(triphenylphosphine)palladium (26 mg, 0.022 mmol), followed by stirring for 12 hours at a room temperature. Then, the reaction mixture was filtered to obtain a filtrate, which was then concentrated and purified by a column chromatography (mobile phase: hexane:ethylacetate=2:3(v:v)) to prepare the titled compound (33 mg, 97%).

Provenance & Evidence