Dimethylformamide → HCID 57763487, compound

Participants

Reaction Conditions

Reaction Steps

To a mixture of 1-{4-[1-ethyl-1-(4-iodo-phenyl)-propyl]-2-methyl-phenoxy}-3,3-dimethyl-butan-2-one (3.0 g 6.27 mmol) and DMF (30 mL) is added Zn(CN)2 (0.44 g, 3.76 mmol), Pd2(dba)3 (0.29 g, 0.31 mmol), and DPPF (0.42 g, 0.75 mmol). The solution is heated at 100° C. overnight, diluted with Et2O (200 mL), washed with 4:1:4 sat NH4Cl:Conc. NH4OH:water (100 mL), water (100 mL), brine (100 mL), dried MgSO4, filtered and concentrated. The residue is purified by ISCO (10%-2-% EtOAc gradient) to furnish the title compound (1.1 g, 2.91 mmol, 46%).

Provenance & Evidence