反应详情

To a mixture of enantiomer 1 of 5-(4-{1-Ethyl-1-[4-(2-hydroxy-3,3-dimethyl-butoxy)-3-methyl-phenyl]-propyl}-2-methyl-benzylidene)-thiazolidine-2,4-dione (0.35 g, 0.71 mmol) and MeOH (10 mL) is added Mg (0.17 g, 7.1 mmol). The solution is heated at a reflux for 4 hours. The solution is filtered thru Celite®, rinsed with MeOH (2 mL), and the solution concentrated. The residue is purified by ISCO (15%-30% EtOAc gradient) to furnish the title compound (0.13 g, 0.26 mmol, 37%).

1. temperatureThe solution is heated at
2. temperaturea reflux for 4 hours
3. filtrationThe solution is filtered
4. washrinsed with MeOH (2 mL)
5. concentrationthe solution concentrated
6. customThe residue is purified by ISCO (15%-30% EtOAc gradient)