3-Chloro-2-methylaniline → 4,7-Dichloro-8-methyl-3-quinolinecarboxamide

HRID 230838Notes

Reaction equation

HRID 230838 reaction equation
[CH3:1][C:2]1[C:8]([Cl:9])=[CH:7][CH:6]=[CH:5][C:3]=1[NH2:4].[Cl:10][C:11]1C2C(=CC=C(I)C=2)N=[CH:13][C:12]=1[C:22]([NH2:24])=[O:23]>>[Cl:10][C:11]1[C:5]2[C:3](=[C:2]([CH3:1])[C:8]([Cl:9])=[CH:7][CH:6]=2)[N:4]=[CH:13][C:12]=1[C:22]([NH2:24])=[O:23]

Participants

3

Reactant 2

HCID 68943-Chloro-2-methylanilineHCID 577632714-Chloro-6-iodoquinoline-3-carboxamide

Product 1

HCID 577632334,7-Dichloro-8-methyl-3-quinolinecarboxamide

Procedure

Intermediate 68 was prepared from 2-methyl-3-chloroaniline (Aldrich) in a similar manner to Intermediate 13.

Sources & evidence

ORD record
ord-c011e72e892c47f798ecff7a58a03f7a
Source dataset
uspto-grants-2009_07
Patent number
US07566786B2

Reaction notes

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