Water → 98961-87-6

Participants

Reaction Conditions

Reaction Steps

392.1 g of anhydrous methanesulfonic acid were added dropwise to 340.8 g of piperidine in 700 ml of isopropanol while stirring and cooling with water over the course of one hour, during which the temperature rose to 75° C. The dropping funnel was washed with 50 ml of isopropanol, and the mixture was then cooled to 25° C. and stirred at this temperature for half an hour. The precipitated product was filtered off with suction, washed twice with 200 ml of diisopropyl ether each time and dried at 50° C. in vacuo. 688.9 g of piperidinium methanesulfonate were obtained as colorless crystals; which is 95% of theory.

Provenance & Evidence