HuagongsheHuagongshe Chemistry Print Report · For research reference only
3-Methoxyaniline → 6-Iodo-4-{[3-(methyloxy)phenyl]amino}-3-quinolinecarboxamide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 3-Methoxyaniline | HCID 10824 | — |
| Reactant | 4-Chloro-6-iodoquinoline-3-carboxamide | HCID 57763271 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | 6-Iodo-4-{[3-(methyloxy)phenyl]amino}-3-quinolinecarboxamide hydrochloride | HCID 67424605 | — |
Reaction Steps
Intermediate 13 (5.0 g) was dissolved in ethanol (60 ml), 3-methoxyaniline (3.37 ml) (available from Aldrich) was added, and the mixture was heated under reflux for 2.5 h. The resulting precipitate was filtered off and washed with ether to give the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07566786B2 |
| Source dataset | uspto-grants-2009_07 |
| ORD ID | ord-37f88493502743c4a8b42cda0fa94fe9 |
| Source note | uspto-grants-2009_07 |